A Facile β-Cyclodextrin-Catalyzed synthesis of substituted benzofuran from salicyaldehyde and alpha tosyl ketone
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چکیده
Benzofuranones have attracted considerable attention with regard to their pharmaceutical activity and the various approaches directed towards their synthesis .The simple benzofuran derivatives like 2-nitrobenzofuran, 2-acetyl benzofurans are well known as bio-dynamic agents possessing various pharmacological properties.spasmolytic activity on the intestine of the guinea pig and dilatory effects on the heart of the rabbit. Most of the benzofuran compounds frequently occur in natural products and are good chelating agents. The compound amiodarone hydrochloride used as an idealantiarrhythmic drug contains a 2, 3-substituted benzofuran moiety. The Schiffs bases exhibit a broad spectrum of pharmacological and biological propertiessuch as analgesic, anticancerous, antiinflammatory etc. that may be due to the azomethine linkage. The Schiffs bases bearing methoxy groups have pronouncedantimicrobial activities. The Schiffs bases derived from sulfa drugs and salicylaldehydes act as good chelating, bactericidal and fungicidal agents.
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